Coronary artery disease and diabetes associated with higher annual growth rate of brain aneurysms

In this study recently presented at the International Stroke Conference, investigators followed a large cohort of patients with known intracranial aneurysms and analyzed demographic and clinical factors that are associated with aneurysm growth.

Not surprisingly, the study found that mean initial size at diagnosis (OR: 1.09, 95% CI: 1.01-1.18, p=0.036), multiple aneurysms (OR: 2.01, 95% CI: 1.00-4.04, p=0.048), and family history (OR: 4.25, 95% CI: 1.18-15.3, p=0.041) were associated with risk of aneurysm growth. Additionally, diagnoses of coronary artery disease (CAD) (p<0.001) and diabetes (p=0.041) were also significant for growth rate. Moreover, there was an increased occurrence of growth at MCA-Bifurcation (p=0.015 vs. other MCA sites) and a high growth rate for those located in the BA trunk (p=0.0033 vs. other VABA sites).

http://stroke.ahajournals.org/content/48/Suppl_1/A200